1. Pyruvate is a key intersection in the network of metabolic pathways.2. Glucagon stimulation of PKA also inactivates the glycolytic enzyme pyruvate kinase. 3. Pyruvate dehydrogenase kinase phosphorylation of these sites leads to decreased dehydrogenase activity4. It is an important anaplerotic reaction that creates oxaloacetate from pyruvate . 5. There are three different enzyme components in the pyruvate dehydrogenase complex. 6. People with pyruvate dehydrogenase deficiency usually have neurological problems as well. 7. This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism. 8. Hence, this enzyme has one products, acetaldehyde and pyruvate . 9. The agarose polymer contains charged groups, in particular pyruvate and sulphate. 10. Alanine is most commonly produced by reductive amination of pyruvate .