Completion of epiboly requires the coordination of cytoskeletal changes across the embryo.
3.
Treating embryos with the actin destabilizer cytochalasin b results in delayed or arrested epiboly.
4.
Cartoon of a 4-hour post fertilization zebrafish embryo, before the initiation of epiboly
5.
The EVL also moves vegetally during epiboly, increasing its surface area as it spreads.
6.
Epiboly has been most extensively studied in zebrafish as their development allows for an easy visualization of the process.
7.
Epiboly in zebrafish is the first coordinated cell movement, and begins once the embryo has completed the blastula stage.
8.
"' Epiboly "'is a cell movement that occurs in the early embryo, at the same time as gastrulation.
9.
Once epiboly is complete, the DEL, EVL, and YSL have engulfed the yolk cell, forming a closure known as the blastopore.
10.
In addition to defining asymmetric axes in the adult organism, cell polarity also regulates both individual and collective cell movements during embryonic development such as apical constriction, invagination, and epiboly.
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