1. In most cases, the center of this focus undergoes caseous necrosis. 2. In caseous necrosis no histological architecture is preserved. 3. However, in the lung, extensive caseous necrosis with confluent cheesy tan granulomas is typical. 4. The ceca experience ulcerations, enlargement, and caseous masses start to form inside of them. 5. The liver develops round, haemorrhagic, 1-2 centimeter oci that have caseous cores. 6. Granulomatous tubercules eventually develop central caseous necrosis and tend to become confluent, replacing the lymphoid tissue. 7. Granulomatous tubercules evolve to central caseous necrosis and tend to become confluent, replacing the lymphoid tissue. 8. To the naked eye, this has the texture of soft, white cheese and is termed caseous necrosis. 9. The conditions under which TMEM251 falls include infantile-onset Pompe disease, caseous tuberculosis granulomas, and endurance exercise training. 10. In a process called caseous necrosis the disc tissue dies leading to vertebral narrowing and eventually to vertebral collapse and spinal damage. 
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