It is thought that the increased flexibility given to the reactive site loop as a result of the hinge region conformational change is a key factor in influencing increased Factor IXa and Xa inhibition.
22.
IgA1 is one of the two immunoglobulin subclasses ( the other is IgD ) that is O-glycosylated on a number of serine and threonine residues in a special proline-rich hinge region.
23.
Prevailing evidence suggests that both galactose-deficient o-glycans in the hinge region of IgA1 and synthesis and binding of antibodies against IgA1 are required for immunoglobulin complexes to form and accumulate in glomeruli.
24.
The protein backbone atoms of residues Glu-211, Ala-213 in the hinge region of Aurora-2, and the sidechain of residue Trp-277, located in the activation loop, bind adenosine through specific hydrogen bonds.
25.
Impact wear and friction wear dictate the loss of material in MHV . Impact wear usually occurs in the hinge regions of bileaflets, between the occluder and ring in tilting-discs, and between the ball and cage in caged-ball valves.
26.
The binding region is a modified single-chain variable fragment ( scFv ), and the rest of the protein can be constructed from the fragment crystallizable region ( Fc ) and the hinge region of an immunoglobulin G 1 ( IgG 1 ).
27.
Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region ( TM ) followed by a very short cytoplasmic tail ( C ).
28.
The conformational change within the hinge region in response to heparin binding results in the expulsion of P14 and P15 from the main body of the protein and it has been shown that by preventing this conformational change, increased Factor IXa and Xa inhibition does not occur.
29.
One or more of the disulfide bonds that join the heavy chains in the hinge region are preserved, so the two Fab regions of the antibody remain joined together, yielding a divalent molecule ( containing two antibody binding sites ), hence the designation F ( ab') 2.
30.
The N-terminal ( A / B ), DNA-binding ( C ), and ligand binding ( E ) domains are independently well folded and structurally stable while the hinge region ( D ) and optional C-terminal ( F ) domains may be conformationally flexible and disordered.
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